Effect of metabolic stress on the expression of mtor kinase in mouse liver cells
Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 148, Issue: 5, Page: 780-784
2009
- 2Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
The time course of changes in mTOR kinase protein and Akt and HSP70 molecular chaperone in hepatic cells was studied in a model system of metabolic stress (48-h food deprivation with subsequent restoration of normal volume of nutrition) on C57Bl/6 mice. The fl uorescence intensity of mTOR protein stained with antibodies decreased in all liver cells during fasting. The expression of mTOR protein in different populations of liver cells was heterogeneous. The percentage of cells with initially high expression of mTOR protein decreased during 48-h food deprivation, while the percentage of cells with low mTOR expression increased. The levels of mTOR, Akt, and HSP70 returned to normal only on day 4 after normalization of nutrition. © 2009 Springer Science+Business Media, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952098718&origin=inward; http://dx.doi.org/10.1007/s10517-010-0815-5; http://www.ncbi.nlm.nih.gov/pubmed/20396791; http://link.springer.com/10.1007/s10517-010-0815-5; https://dx.doi.org/10.1007/s10517-010-0815-5; https://link.springer.com/article/10.1007/s10517-010-0815-5; http://www.springerlink.com/index/10.1007/s10517-010-0815-5; http://www.springerlink.com/index/pdf/10.1007/s10517-010-0815-5
Springer Science and Business Media LLC
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