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Original nerve growth factor mimetic dipeptide GK-2 limits the manifestations of hemorrhagic stroke in rats

Bulletin of Experimental Biology and Medicine, ISSN: 0007-4888, Vol: 154, Issue: 5, Page: 642-644
2013
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The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in a dose of 1 mg/kg 4 and 24 h after surgery and 24 h before testing the CNS function on days 3, 7, and 14 prevent death of experimental animals, reduce the neurological deficit, and normalized behavior. © 2013 Springer Science+Business Media New York.

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