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Changes in the Expression of Pluripotency Factor Oct-4 and Intensity of Apoptosis in the Uterus during Spontaneous and Immune-Dependent Abortions in Mice

Bulletin of Experimental Biology and Medicine, ISSN: 1573-8221, Vol: 172, Issue: 6, Page: 765-769
2022
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Article Description

We studied the expression of pluripotency factor Oct-4 and the intensity of apoptosis in the uterus during spontaneous and immune abortions in mice. Increased expression of factor Bax and reduced protein Bcl-2 synthesis in cells of the decidual membrane and decreased Oct-4 expression in the myometrium and perimetrium were detected. Thus, both spontaneous and immune-dependent abortions impair the apoptosis processes in the decidua and the formation of a pool of Oct-4 cells in the uterus. In immune-dependent abortions, the intensity of apoptosis of decidual cells was lower than in spontaneous abortion. Low expression of the transcription factor Oct-4 in the myometrium and perimetrium characterizes pregnancy failure irrespective of its mechanisms.

Bibliographic Details

K. A. Artem’eva; I. I. Stepanova; I. M. Bogdanova; M. N. Boltovskaya; N. V. Yaglova; S. V. Obernikhin; E. A. Ponomarenko

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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