PlumX Metrics
Embed PlumX Metrics

Airway Smooth Muscles Contractions in Metabolic Syndrome

Bulletin of Experimental Biology and Medicine, ISSN: 1573-8221, Vol: 173, Issue: 4, Page: 486-489
2022
  • 0
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

We studied contractile responses of isolated airway smooth muscle segments from rats with metabolic syndrome. Metabolic syndrome was induced in rats by high-fat and high-carbohydrate diet. It was shown that metabolic syndrome was associated with an increase of bronchoconstrictor action of cholinergic receptor activator carbacholine (0.1-100 μM) and a decrease of the dilatory effect of β-adrenoreceptor activator salbutamol (0.1-100 μM). The observed effects of agonists are epithelium-dependent. Disorders in contractile activity in the airway smooth muscles were accompanied by bronchial epithelium destruction, immune inflammation in the bronchial wall, muscular and peribronchial adipose tissue hypertrophy.

Bibliographic Details

Yu. G. Birulina; V. V. Ivanov; E. E. Buiko; A. N. Dzyuman; A. V. Nosarev; O. V. Voronkova; M. O. Vol’khina; S. V. Gusakova

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know