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Effect of Adrenoreceptor Stimulation on Peptidergic Regulation of Cardiac Activity in Newborn Rats

Bulletin of Experimental Biology and Medicine, ISSN: 1573-8221, Vol: 176, Issue: 1, Page: 9-13
2023
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Article Description

We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction of the atrial myocardial strips from newborn rats, as well as the effect of Y receptor stimulation against the background of adrenoreceptor activation. After addition of Y receptor agonist [Leu31, Pro34] NPY (10 M), a tendency to a decrease in the effect of β-adrenoreceptor agonist isoproterenol (10 M) on the frequency of spontaneous activity and atrial myocardial contractility was observed. The age-related features of the effect of NPY on the frequency of spontaneous activity and contractility of myocardial strips from newborn and adult rats were revealed.

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