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Nanoscale fabrication of a peptide layer in cell chip to detect effects of environmental toxins on HEK293 cells

Biotechnology Letters, ISSN: 0141-5492, Vol: 32, Issue: 12, Page: 1797-1802
2010
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Article Description

A cysteine-terminated C(RGD) peptide film was fabricated on a gold electrode for improving the attachment of cells. The electrochemical signals of cyclic voltammogram from cells on a C(RGD) deposited electrode was enhanced from 0.27 to 0.49 μA compared to a bare electrode. The developed cell-based sensor determined the effect of bisphenol-A (BPA) and dichlorodiphenyltrichloroethane (DTT) on the viability of HEK-293 cells by detecting decrease of reduction peaks (1.12-0.15 μA for BPA and 0.81-0.29 μA for DDT) after the treatment of environmental chemicals. This developed system can be a powerful tool for the monitoring of environmental toxicants. © 2010 Springer Science+Business Media B.V.

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