Production of caffeoylmalic acid from glucose in engineered Escherichia coli
Biotechnology Letters, ISSN: 1573-6776, Vol: 40, Issue: 7, Page: 1057-1065
2018
- 21Citations
- 25Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef2
- Captures25
- Readers25
- 25
Article Description
Objectives: To achieve biosynthesis of caffeoylmalic acid from glucose in engineered Escherichia coli. Results: We constructed the biosynthetic pathway of caffeoylmalic acid in E. coli by co-expression of heterologous genes RgTAL, HpaBC, At4CL2 and HCT2. To enhance the production of caffeoylmalic acid, we optimized the tyrosine metabolic pathway of E. coli to increase the supply of the substrate caffeic acid. Consequently, an E. coli–E. coli co-culture system was used for the efficient production of caffeoylmalic acid. The final titer of caffeoylmalic acid reached 570.1 mg/L. Conclusions: Microbial production of caffeoylmalic acid using glucose has application potential. In addition, microbial co-culture is an efficient tool for producing caffeic acid esters.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047666109&origin=inward; http://dx.doi.org/10.1007/s10529-018-2580-x; http://www.ncbi.nlm.nih.gov/pubmed/29845386; http://link.springer.com/10.1007/s10529-018-2580-x; https://dx.doi.org/10.1007/s10529-018-2580-x; https://link.springer.com/article/10.1007/s10529-018-2580-x
Springer Science and Business Media LLC
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