Biological and cytoselective anticancer properties of copper(II)- polypyridyl complexes modulated by auxiliary methylated glycine ligand
BioMetals, ISSN: 0966-0844, Vol: 25, Issue: 5, Page: 1061-1081
2012
- 42Citations
- 55Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef31
- Captures55
- Readers55
- 55
Article Description
A series of ternary copper(II)-1,10-phenanthroline complexes with glycine and methylated glycine derivatives, [Cu(phen)(aa)(HO)]NO xHO 1-4 (amino acid (aa): glycine (gly), 1; DL-alanine (DL-ala), 2; 2,2-dimethylglycine (C-dmg), 3; sarcosine (sar), 4), were synthesized and characterized by FTIR, elemental analysis, electrospray ionization-mass spectra (ESI-MS), UV-visible spectroscopy and molar conductivity measurement. The determined X-ray crystallographic structures of 2 and 3 show selectively to DNA by intercalation and electrostatic forces, and inhibit topoisomerase I. The effect of the methyl substituents of the coordinated amino acid in the above complexes on these biological properties are presented and discussed. The IC values (24 h) of 1-4 for nasopharyngeal cancer cell line HK1 are in the range 2.2-5.2 μM while the corresponding values for normal cell line NP69 are greater than 13.0 lM. All complexes, at 5 μM, induced 41-60 % apoptotic cell death in HK1 cells but no significant cell death in NP69 cells. © Springer Science+Business Media, LLC. 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84868098360&origin=inward; http://dx.doi.org/10.1007/s10534-012-9572-4; http://www.ncbi.nlm.nih.gov/pubmed/22836829; http://link.springer.com/10.1007/s10534-012-9572-4; https://dx.doi.org/10.1007/s10534-012-9572-4; https://link.springer.com/article/10.1007/s10534-012-9572-4; http://www.springerlink.com/index/10.1007/s10534-012-9572-4; http://www.springerlink.com/index/pdf/10.1007/s10534-012-9572-4
Springer Science and Business Media LLC
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