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Biological and cytoselective anticancer properties of copper(II)- polypyridyl complexes modulated by auxiliary methylated glycine ligand

BioMetals, ISSN: 0966-0844, Vol: 25, Issue: 5, Page: 1061-1081
2012
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Article Description

A series of ternary copper(II)-1,10-phenanthroline complexes with glycine and methylated glycine derivatives, [Cu(phen)(aa)(HO)]NO xHO 1-4 (amino acid (aa): glycine (gly), 1; DL-alanine (DL-ala), 2; 2,2-dimethylglycine (C-dmg), 3; sarcosine (sar), 4), were synthesized and characterized by FTIR, elemental analysis, electrospray ionization-mass spectra (ESI-MS), UV-visible spectroscopy and molar conductivity measurement. The determined X-ray crystallographic structures of 2 and 3 show selectively to DNA by intercalation and electrostatic forces, and inhibit topoisomerase I. The effect of the methyl substituents of the coordinated amino acid in the above complexes on these biological properties are presented and discussed. The IC values (24 h) of 1-4 for nasopharyngeal cancer cell line HK1 are in the range 2.2-5.2 μM while the corresponding values for normal cell line NP69 are greater than 13.0 lM. All complexes, at 5 μM, induced 41-60 % apoptotic cell death in HK1 cells but no significant cell death in NP69 cells. © Springer Science+Business Media, LLC. 2012.

Bibliographic Details

Seng, Hoi-Ling; Wang, Wai-San; Kong, Siew-Ming; Alan Ong, Han-Kiat; Win, Yip-Foo; Raja Abd Rahman, Raja Noor Zaliha; Chikira, Makoto; Leong, Weng-Kee; Ahmad, Munirah; Khoo, Alan Soo-Beng; Ng, Chew-Hee

Springer Science and Business Media LLC

Materials Science; Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences

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