Radiotherapy for ductal carcinoma in situ and risk of second non-breast cancers
Breast Cancer Research and Treatment, ISSN: 1573-7217, Vol: 166, Issue: 1, Page: 299-306
2017
- 17Citations
- 36Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations17
- Citation Indexes17
- 17
- Captures36
- Readers36
- 36
Article Description
Purpose: Radiotherapy for ductal carcinoma (DCIS) is increasing, but the risks and benefits of the treatment remain uncertain. We aimed to investigate the relationship between radiotherapy for DCIS and risk of second non-breast cancers in a large US cohort. Methods: We conducted a retrospective cohort study of 52,556 women in 12 U.S. population-based cancer registries diagnosed with first primary DCIS during 1992–2008 at age 25–79 years. We estimated relative risks (RRs), attributable risks (AR), and excess absolute risks (EAR) of second non-breast cancers associated with radiotherapy using Poisson regression adjusted for age at year of diagnosis, grade, hormonal therapy (yes/no or unknown), and time since diagnosis. Results: Approximately half of the women (46.3%) received radiotherapy. Radiotherapy was associated with an increased risk of all second non-breast cancers combined [RR 1.17, 95% confidence interval (CI) 1.08–1.28] and all in-field, radiation-related second cancers combined (RR 1.37, 95% CI 1.15–1.63), driven by second lung cancers (RR 1.33, 95% CI 1.10–1.60) and non-CLL leukemia (RR 1.71, 95% CI 1.02–2.86). The estimated cumulative excess risk of all second non-breast cancers was 0.8% by 15 years after DCIS diagnosis. Conclusions: Radiotherapy was associated with an increased risk of second non-breast cancers. The specific excess of cancers at sites likely in/near the radiotherapy field suggests the findings are unlikely due exclusively to confounding, but further research into factors related to receipt of radiotherapy is needed. Our risk estimates can be used to help assess the balance of the risks and benefits of radiotherapy for DCIS and to inform clinical practice.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85025802760&origin=inward; http://dx.doi.org/10.1007/s10549-017-4410-6; http://www.ncbi.nlm.nih.gov/pubmed/28744752; http://link.springer.com/10.1007/s10549-017-4410-6; https://dx.doi.org/10.1007/s10549-017-4410-6; https://link.springer.com/article/10.1007/s10549-017-4410-6
Springer Nature
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