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Reductive acid-catalyzed rearrangement of 3-(2-nitrobenzyl)quinoxalin-2(1Н)-ones in the presence of NaSO – effective method for the synthesis of 2-(indol-2-yl)benzimidazoles

Chemistry of Heterocyclic Compounds, ISSN: 1573-8353, Vol: 53, Issue: 9, Page: 1033-1044
2017
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[Figure not available: see fulltext.] An effective one-step method is proposed for the synthesis of 2-(indol-2-yl)benzimidazoles from 3-(2-nitrobenzyl)quinoxalin-2(1Н)-ones without using metal catalysts and reagents. This method is based on the Mamedov rearrangement of 3-(2-aminobenzyl)quinoxalin-2(1Н)-ones, formed in situ by the action of NaSO, giving 2-(indol-2-yl)benzimidazoles as the products.

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