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Total synthesis of hamacanthin B class marine bisindole alkaloids

Chemistry of Heterocyclic Compounds, ISSN: 1573-8353, Vol: 56, Issue: 3, Page: 331-338
2020
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[Figure not available: see fulltext.] A method for the synthesis of 1-(1H-indol-3-yl)ethane-1,2-diamines, key synthetic precursors of a number of marine alkaloids, has been developed based on the reduction of adducts of O-benzylhydroxylamine and N-protected 3-(2-nitrovinyl)indoles. For the first time, the total synthesis of 6’,6”-didebromohamacanthin B, 6’-debromohamacanthin B, and 6”-debromohamacanthin B, the secondary metabolites of the sponges Spongosorites and Discodermia calyx, was carried out.

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