Four Verrucosidin Derivatives Isolated from the Hydrothermal Vent Sulfur-Derived Fungus Penicillium sp. Y-50-10
Chemistry of Natural Compounds, ISSN: 1573-8388, Vol: 54, Issue: 2, Page: 253-256
2018
- 10Citations
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Article Description
Four verrucosidin derivatives, penicyrone (1), norpenicyrone (2), methyl norpenicyrone (3), and methyl penicyrone (4) were isolated from the hydrothermal vent sulfur-derived fungus Penicillium sp. Y-50-10. Compounds 1–4 were obtained as a mixture of two epimers. Compounds 2–4 have been proved to be new secondary metabolites. The chemical structures were determined by comparing with literature data and HR-MS and 2D NMR spectroscopic analysis. The migration of the double bond from C=C to C=C in compounds 1–4 allowed the assignment of a rearranged verrucosidin skeleton. Compounds 1–4 showed activity against B. subtilis, with MIC values of 32 μg/mL.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85045431099&origin=inward; http://dx.doi.org/10.1007/s10600-018-2316-0; http://link.springer.com/10.1007/s10600-018-2316-0; http://link.springer.com/content/pdf/10.1007/s10600-018-2316-0.pdf; http://link.springer.com/article/10.1007/s10600-018-2316-0/fulltext.html; https://dx.doi.org/10.1007/s10600-018-2316-0; https://link.springer.com/article/10.1007/s10600-018-2316-0
Springer Nature
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