Corticosteroids modulate angiogenic soluble factors in ulcerative colitis patients
Digestive Diseases and Sciences, ISSN: 0163-2116, Vol: 56, Issue: 3, Page: 871-879
2011
- 10Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef5
- Captures12
- Readers12
- 12
Article Description
Aims: The aim of this study was to compare angiogenic factors in serum levels of active ulcerative colitis (UC) patients and in healthy controls, and to analyze these angiogenic levels depending on the achievement of remission after oral corticosteroid treatment throughout treatment, and according to the Truelove-Witts activity index. Methods: Blood samples were collected from 13 patients receiving oral corticosteroids for treatment of UC flares at three different intervals-baseline, during, and after treatment-and from 26 healthy controls. Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), VEGF receptor 1 (VEGFR1), angiopoietins (Ang) 1 and 2, and its receptor Tie2 were assayed by ELISA. Results: While VEGF and Ang2 levels in UC patients were higher than in healthy controls (P < 0.05), UC patients showed lower levels of Ang1 than healthy individuals (P < 0.05). In UC patients who achieved clinical remission after corticosteroid treatment, a statistically significant higher baseline serum level of PlGF was observed (22 ± 5 vs. 18 ± 2; P < 0.05). Angiogenic factor levels varied during treatment; however, they did not show a statistically significant correlation to the activity of the disease. Conclusions: VEGF, Ang1, and Ang2 levels showed statistically significant differences between UC patients and healthy controls. Although determination of PlGF serum levels before corticosteroid treatment might be helpful to anticipate the response by UC patients, no angiogenic pattern that could accurately predict "a priori" this response to corticosteroid treatment was observed. Corticosteroids altered temporarily circulating levels of VEGF, angiopoietins and Tie2. No correlation was found between systemic levels of angiogenic factors and the clinical activity of UC. © 2010 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952442544&origin=inward; http://dx.doi.org/10.1007/s10620-010-1327-x; http://www.ncbi.nlm.nih.gov/pubmed/20632101; http://link.springer.com/10.1007/s10620-010-1327-x; https://dx.doi.org/10.1007/s10620-010-1327-x; https://link.springer.com/article/10.1007/s10620-010-1327-x; http://www.springerlink.com/index/10.1007/s10620-010-1327-x; http://www.springerlink.com/index/pdf/10.1007/s10620-010-1327-x
Springer Science and Business Media LLC
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