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Long-term prognosis after kidney donation: a propensity score matched comparison of living donors and non-donors from two population cohorts

European Journal of Epidemiology, ISSN: 1573-7284, Vol: 35, Issue: 7, Page: 699-707
2020
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Article Description

Background: Live donor nephrectomy is a safe procedure. However, long-term donor prognosis is debated, necessitating high-quality studies. Methods: A follow-up study of 761 living kidney donors was conducted, who visited the outpatient clinic and were propensity score matched and compared to 1522 non-donors from population-based cohort studies. Primary outcome was kidney function. Secondary outcomes were BMI (kg/m), incidences of hypertension, diabetes, cardiovascular events, cardiovascular and overall mortality, and quality of life. Results: Median follow-up after donation was 8.0 years. Donors had an increase in serum creatinine of 26 μmol/l (95% CI 24–28), a decrease in eGFR of 27 ml/min/1.73 m (95% CI − 29 to − 26), and an eGFR decline of 32% (95% CI 30–33) as compared to non-donors. There was no difference in outcomes between the groups for ESRD, microalbuminuria, BMI, incidence of diabetes or cardiovascular events, and mortality. A lower risk of new-onset hypertension (OR 0.45, 95% CI 0.33–0.62) was found among donors. The EQ-5D health-related scores were higher among donors, whereas the SF-12 physical and mental component scores were lower. Conclusion: Loss of kidney mass after live donation does not translate into negative long-term outcomes in terms of morbidity and mortality compared to non-donors. Trial registration: Dutch Trial Register NTR3795.

Bibliographic Details

Janki, Shiromani; Dehghan, Abbas; van de Wetering, Jacqueline; Steyerberg, Ewout W; Klop, Karel W J; Kimenai, Hendrikus J A N; Rizopoulos, Dimitris; Hoorn, Ewout J; Stracke, Sylvia; Weimar, Willem; Völzke, Henry; Hofman, Albert; Ijzermans, Jan N M

Springer Science and Business Media LLC

Medicine

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