Predicting methotrexate resistance in rheumatoid arthritis patients
Inflammopharmacology, ISSN: 1568-5608, Vol: 26, Issue: 3, Page: 699-708
2018
- 28Citations
- 52Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations28
- Citation Indexes28
- 28
- CrossRef3
- Captures52
- Readers52
- 52
- Mentions1
- News Mentions1
- News1
Most Recent News
Patterns of Cytopenias Associated with Methotrexate Treated Rheumatoid Arthritis Patients
Keywords: Cytopenia, Methotrexate, Rheumatoid arthritis. INTRODUCTION Immune-based diseases have been diagnosed more in the last two decades, and rheumatoid arthritis has been one of the
Review Description
Rheumatoid arthritis (RA) is an incurable, systemic autoimmune disease that decreases quality of life and can lead to severe disability. While there are many medications available to treat RA, the first-line of therapy is low-dose methotrexate (MTX), a small molecule disease-modifying anti-rheumatic drug (DMARD). MTX is the recommended therapy due to its affordability and efficacy in reducing symptoms in most RA patients. Unfortunately, there is great person-to-person variability in the physiological response to MTX, with up to 50% of patients showing little response to the medication. Thus, many RA patients initially placed on MTX do not experience an adequate reduction of symptoms, and could have benefited more in both the short and long terms if initially prescribed a different drug that was more effective for them. To combat this problem and better guide treatment decisions, many research groups have attempted to develop predictive tools for MTX response. Currently, there is no reliable, clinical-grade method to predict an individual’s response to MTX treatment. In this review, we describe progress made in the area of MTX non-response/resistance in RA patients. We specifically focus on application of the following elements as predictive markers: proteins related to MTX transport and function, intracellular MTX concentration, immune cell frequencies, cytokines, and clinical factors.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85043451210&origin=inward; http://dx.doi.org/10.1007/s10787-018-0459-z; http://www.ncbi.nlm.nih.gov/pubmed/29532212; http://link.springer.com/10.1007/s10787-018-0459-z; https://dx.doi.org/10.1007/s10787-018-0459-z; https://link.springer.com/article/10.1007/s10787-018-0459-z
Springer Nature
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