Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder
Journal of Autism and Developmental Disorders, ISSN: 0162-3257, Vol: 39, Issue: 11, Page: 1542-1551
2009
- 62Citations
- 158Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations62
- Citation Indexes62
- 62
- CrossRef44
- Captures158
- Readers158
- 158
Article Description
The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp = 0.10) and teacher-rated tics (p = 0.04; ηp = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp = 0.09) of BDNF genotype with DAT1 3VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. © 2009 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349909427&origin=inward; http://dx.doi.org/10.1007/s10803-009-0794-4; http://www.ncbi.nlm.nih.gov/pubmed/19582565; http://link.springer.com/10.1007/s10803-009-0794-4; http://www.springerlink.com/index/10.1007/s10803-009-0794-4; http://www.springerlink.com/index/pdf/10.1007/s10803-009-0794-4; https://dx.doi.org/10.1007/s10803-009-0794-4; https://link.springer.com/article/10.1007/s10803-009-0794-4
Springer Science and Business Media LLC
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