Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: A meta-analysis
Journal of Assisted Reproduction and Genetics, ISSN: 1058-0468, Vol: 29, Issue: 9, Page: 921-932
2012
- 26Citations
- 24Captures
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Metrics Details
- Citations26
- Citation Indexes26
- 26
- CrossRef11
- Captures24
- Readers24
- 24
Article Description
Purpose: There have been many studies concerning the associations of angiotensin-converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T polymorphisms with pregnancy induced hypertension (PIH) among Chinese populations. However, the results were inconsistent, prompting the necessity of meta-analysis. Methods: Studies published in English and Chinese were mainly searched in EMbase, PubMed and CBMup to January 2012. Results: Twenty-three studies with 3,551 subjects for ACE I/D and seven studies with 1,296 subjects for AGT M235T were included. Significant associations were found between ACE I/D and PIH under dominant, recessive and allelic models. A separate analysis confined to preeclampsia suggested that ACE I/D was associated with preeclampsia under recessive model and allelic model, but not dominant model. Stratified analyses were conducted as meta-regression analysis indicated that the sample size of case group was a significant source of heterogeneity, which suggested no significant association between ACE I/D and PIH in the subgroup of more than 100 cases. Associations were found between AGT M235T and PIH under dominant genetic model (OR01.59;95 %CI: 1.04-2.42), recessive genetic model (OR01.60;95 %CI: 1.07-2.40), and allelic model (OR01.40;95 %CI: 1.17-1.68). No publication bias was found in either meta-analysis. Conclusions: The present meta-analysis suggested significant associations between ACE I/D, AGT M235T and PIH in Chinese populations. However, no significant association was found between ACE I/D and PIH in the subgroup of more than 100 cases. Studies with larger sample sizes are necessary to investigate the associations between gene polymorphisms and PIH in Chinese populations. © Springer Science+Business Media, LLC 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867398431&origin=inward; http://dx.doi.org/10.1007/s10815-012-9800-4; http://www.ncbi.nlm.nih.gov/pubmed/22644634; http://link.springer.com/10.1007/s10815-012-9800-4; http://www.springerlink.com/index/10.1007/s10815-012-9800-4; http://www.springerlink.com/index/pdf/10.1007/s10815-012-9800-4; https://dx.doi.org/10.1007/s10815-012-9800-4; https://link.springer.com/article/10.1007/s10815-012-9800-4
Springer Science and Business Media LLC
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