Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population
Journal of Assisted Reproduction and Genetics, ISSN: 1573-7330, Vol: 32, Issue: 3, Page: 369-374
2015
- 30Citations
- 25Captures
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Metrics Details
- Citations30
- Citation Indexes30
- 30
- CrossRef22
- Captures25
- Readers25
- 25
Article Description
Purpose: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods: The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results: We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925512311&origin=inward; http://dx.doi.org/10.1007/s10815-014-0423-9; http://www.ncbi.nlm.nih.gov/pubmed/25578539; http://link.springer.com/10.1007/s10815-014-0423-9; https://dx.doi.org/10.1007/s10815-014-0423-9; https://link.springer.com/article/10.1007/s10815-014-0423-9
Springer Science and Business Media LLC
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