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Close-packed array of gold nanoparticles and sum frequency generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors

Journal of Materials Science, ISSN: 0022-2461, Vol: 44, Issue: 24, Page: 6805-6810
2009
  • 15
    Citations
  • 0
    Usage
  • 18
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    15
    • Citation Indexes
      15
  • Captures
    18

Conference Paper Description

An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the sum frequency generation spectroscopy performed in the total internal reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers. © 2009 Springer Science+Business Media, LLC.

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