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Adsorption and release of diphenhydraminium ibuprofenate from SBA-15 and MCM-41 explained by intermolecular interactions

Journal of Materials Science, ISSN: 1573-4803, Vol: 58, Issue: 16, Page: 6998-7010
2023
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Article Description

The loading of Active Pharmaceutical Ingredient Ionic Liquid (API-IL)—diphenhydraminium ibuprofenate ([DIP][IBU])—on mesoporous silica (SBA-15 and MCM-41) was evaluated from intermolecular interactions point-of-view, which advance from a discussion focused on surface area and pore volume of silica matrices. The rate of [DIP][IBU] release was also evaluated in two different mediums (PBS pH 7.2 with 1% Tween 80®, and in SGF pH 1.2). The solid-state H, C, and Si MAS NMR and thermal analysis showed that [DIP][IBU] effectively interacts with the silica and that this interaction is stronger with SBA-15 than with MCM-41. Meanwhile, the fastest release occurred from SBA-15, which was probably due to its larger pore size than the MCM-41. These results led us to conclude that the intermolecular interaction between [DIP][IBU] and the silicas influences the loading stability, but the release is controlled by the geometrical properties of the silicas. Graphical abstract: [Figure not available: see fulltext.]

Bibliographic Details

Jean C. B. Vieira; Vithória E. Priebe; Keli M. Wust; Edilson V. Benvenuti; Marcos A. Villetti; Caroline R. Bender; Clarissa P. Frizzo

Springer Science and Business Media LLC

Materials Science; Engineering

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