On the biocompatibility of a novel Ti-based amorphous composite: Structural characterization and in-vitro osteoblasts response
Journal of Materials Science: Materials in Medicine, ISSN: 0957-4530, Vol: 19, Issue: 5, Page: 1861-1869
2008
- 14Citations
- 25Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef7
- Captures25
- Readers25
- 25
Article Description
Titanium and its alloys are frequently used as dental and orthopaedic implants due to their high mechanical strength, low elastic modulus and biocompatibility. However, as these materials have a poor wear resistance, tribo-chemical reactions during use produce debris accumulation, resulting in adverse cellular responses. In that sense, amorphous based materials are potential candidates, considering their hardness and crack growth resistance. This paper reports on the structural characterization of the as-quenched Ti ZrNi alloy. This system displays a duplex structure never mentioned before with a low dispersion of nanometric beta-phase particles in an amorphous matrix. Moreover, in order to explore the biocompatibility of such composite, primary osteoblasts cultures are used to analyse cell behaviour around and upon the metallic surface. Osteoblasts attach and proliferate on the material as demonstrated by scanning electron microscopy. Cell proliferation and bone nodule formation are also observed in cultures with TiZrNi particles by phase contrast microscope. In addition, transmission electron microscopy reveals ultrastructural features very close to those observed in vivo during intramembranous ossification with active osteoblasts surrounded by an extracellular matrix and a mineralized one. In conclusion, these results demonstrate that osteoblasts, cultured in presence of TiZr Ni alloy, proliferate, differentiate and synthesize bone matrix. © 2007 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41149092126&origin=inward; http://dx.doi.org/10.1007/s10856-007-3248-6; http://www.ncbi.nlm.nih.gov/pubmed/17914625; http://link.springer.com/10.1007/s10856-007-3248-6; https://dx.doi.org/10.1007/s10856-007-3248-6; https://link.springer.com/article/10.1007/s10856-007-3248-6; http://www.springerlink.com/index/10.1007/s10856-007-3248-6; http://www.springerlink.com/index/pdf/10.1007/s10856-007-3248-6
Springer Science and Business Media LLC
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