Translational approaches using metastasis suppressor genes
Journal of Bioenergetics and Biomembranes, ISSN: 0145-479X, Vol: 38, Issue: 3-4, Page: 151-161
2006
- 47Citations
- 36Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations47
- Citation Indexes47
- 47
- CrossRef41
- Captures36
- Readers36
- 36
Article Description
Cancer metastasis is a significant contributor to breast cancer patient morbidity and mortality. In order to develop new anti-metastatic therapies, we need to understand the biological and biochemical mechanisms of metastasis. Toward these efforts, we and others have studied metastasis suppressor genes, which halt metastasis in vivo without affecting primary tumor growth. The first metastasis suppressor gene identified was nm23, also known as NDP kinase. Nm23 represents the most widely validated metastasis suppressor gene, based on transfection and knock-out mouse strategies. The biochemical mechanism of metastasis suppression via Nm23 is unknown and likely complex. Two potential mechanisms include binding proteins and a histidine kinase activity. Elevation of Nm23 expression in micrometastatic tumor cells may constitute a translational strategy for the limitation of metastatic colonization in high risk cancer patients. To date, medroxyprogesterone acetate (MPA) has been identified as a candidate compound for clinical testing. © 2006 Springer Science+Business Media, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845666986&origin=inward; http://dx.doi.org/10.1007/s10863-006-9039-9; http://www.ncbi.nlm.nih.gov/pubmed/16944301; http://link.springer.com/10.1007/s10863-006-9039-9; https://dx.doi.org/10.1007/s10863-006-9039-9; https://link.springer.com/article/10.1007/s10863-006-9039-9; http://www.springerlink.com/index/10.1007/s10863-006-9039-9; http://www.springerlink.com/index/pdf/10.1007/s10863-006-9039-9
Springer Science and Business Media LLC
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