Increased vulnerability of brain to estrogen withdrawal-induced mitochondrial dysfunction with aging
Journal of Bioenergetics and Biomembranes, ISSN: 0145-479X, Vol: 40, Issue: 6, Page: 625-630
2008
- 16Citations
- 7Captures
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Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef14
- Captures7
- Readers7
Article Description
In the present study, to determine whether aging could increase the vulnerability of the brain to estrogen withdrawal-induced mitochondrial dysfunction, we measured the cytochrome c oxidase (COX) activity and mitochondrial adenosine triphosphate (ATP) content in hippocampi of 2 groups of ovariectomized (OVX) Wistar rats aged 2 months (young) and 9 months (middle-aged), respectively. In addition, effects of genistein and estradiol benzoate (EB) were tested also. We observed only a transient alteration of COX activity and mitochondrial ATP content in hippocampi of young OVX rats but a prolonged lowering of COX activity and mitochondrial ATP content in hippocampi of middle-aged OVX rats. This suggested that with aging compensatory mechanisms of mitochondrial function were attenuated, thus exacerbated estrogen withdrawal-induced mitochondrial dysfunction in hippocampi. Significantly, EB/genistein treatment reversed this estrogen withdrawal-induced mitochondrial dysfunction in both young and middle-aged rats suggesting that genistein may be used as a substitute for estradiol to prevent age-related disease such as Alzheimer's disease in post-menopausal females. © 2009 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=60849096071&origin=inward; http://dx.doi.org/10.1007/s10863-008-9195-1; http://www.ncbi.nlm.nih.gov/pubmed/19139976; http://link.springer.com/10.1007/s10863-008-9195-1; https://dx.doi.org/10.1007/s10863-008-9195-1; https://link.springer.com/article/10.1007/s10863-008-9195-1; http://www.springerlink.com/index/10.1007/s10863-008-9195-1; http://www.springerlink.com/index/pdf/10.1007/s10863-008-9195-1
Springer Science and Business Media LLC
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