Crystal structure of a benzimidazole hepatitis C virus inhibitor free and in complex with the viral RNA target
Journal of Chemical Crystallography, ISSN: 1074-1542, Vol: 43, Issue: 5, Page: 235-239
2013
- 4Citations
- 8Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations4
- Citation Indexes4
- CrossRef3
- Captures8
- Readers8
Article Description
The crystal structure of 8-((dimethylamino)methyl)-1-(3-(dimethylamino) propyl)-1,7,8,9-tetrahydrochromeno[5,6-d]imidazol-2-amine (1), an inhibitor of the hepatitis C virus internal ribosome entry site, is described and compared to the structure of the compound in complex with the viral RNA target. Compound 1 crystallized by pentane vapor diffusion into dichloroethane solution. It crystallized in the monoclinic system, P2/c space group with unit cell parameters a = 15.7950(5) Å, b = 14.0128(4) Å, c = 8.8147(3) Å, β = 94.357(2)° and a cell volume of 1945.34(11) A . Packing interactions in the small molecule crystal lattice correspond to key interactions of the compound with the viral RNA target. © 2013 Springer Science+Business Media New York.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880743141&origin=inward; http://dx.doi.org/10.1007/s10870-013-0410-5; http://www.ncbi.nlm.nih.gov/pubmed/23750099; http://link.springer.com/10.1007/s10870-013-0410-5; https://dx.doi.org/10.1007/s10870-013-0410-5; https://link.springer.com/article/10.1007/s10870-013-0410-5
Springer Science and Business Media LLC
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