Treatment Activity of a New Pr(III) Coordination Polymer on Diabetic Retinopathy by Regulating miR-107/HMGB1 in Retinal Vascular Cells

A lanthanide coordination polymer (Ln-CP), {Pr(PBA)(HO)]·DMF·3HO} (1), was synthesized using 5-(4-pyridin-3-yl-benzoylamino)-isophthalic acid (HPBA), a tripodal carboxylic ligand. Moreover, the relative expression of miR-107 was evaluated through RT-PCR. miR-107 effect was then detected with the CCK-8 assay. ROS detection and ELISA were used to assess the inflammatory response in retinal vascular cells. miR-107 downstream regulation was also investigated. TargetScan was applied to predict the latent proteins that bind to miR-107 via the 3′-UTR, which was demonstrated in-depth through luciferase activity assay. All outcomes indicated that the miR-107 level was lower in retinal vascular cells in a diabetic retinopathy (DR) model. miR-107 expression could further regulate the proliferation of retinal vascular cells and inhibit inflammation, thereby playing a protective role in the function of retinal vascular cells. Thus, miR-107 may be an upstream regulatory factor of high-mobility group box 1, and let 7-5p may be a latent molecular target to treat DR.