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A Highly Selective Fluorescent Probe for Hydrogen Sulfide and its Application in Living Cell

Journal of Fluorescence, ISSN: 1573-4994, Vol: 35, Issue: 2, Page: 1163-1169
2025
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Article Description

A new Near-infrared fluorescent probe for hydrogen sulfide detection was synthesized by employing dicyanoisophorone based fluorescence dye as a fluorophore and methyl 3-(2-(carbonyl)phenyl)-2-cyanoacrylate group as the response unit. The Probe DCI-HS showed a long emission wavelength (λem = 674 nm). Based on the HS-induced addition–cyclization of deprotecting methyl 3-(2-(carbonyl)phenyl)-2-cyanoacrylate group, the probe DCI-HS showed high selectivity, sensitivity and response speed toward hydrogen sulfide under room temperature. These numerous advantages of the probe DCI-HS make it to potentially detect endogenous hydrogen sulfide in living organisms.

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