Development of Biocompatible Barium peroxide/Pluronic F127/L-ornithine Composite for Enriched Antimicrobial, Antioxidant and Anticancer Potential: An in vitro Study
Journal of Inorganic and Organometallic Polymers and Materials, ISSN: 1574-1451
2024
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Article Description
Osteosarcoma (MG-63) is a type of bone cancer affects mostly adolescents and young adults. Disease-causing microorganisms like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans pose serious illness in humans. There is a need to develop multifunctional composite to combat cancer and other most common disease caused by disease causing microorganisms. In this context, BaO and pluronic F127, L-Ornithine coated BaO (BaO-PF127-LO) composite have been prepared and characterized by XRD, FTIR, UV-Vis, SEM, HRTEM, EDAX, and XPS analytical techniques. BaO and BaO-PF127-LO were orthorhombic crystalline structure and the crystallite size was found as 32 nm for BaO and 26 nm for modified BaO PL studies revealed the green emission observed at 506 nm for BaO-PF127-LO composite which is absent in the case of bare BaO. Antimicrobial activity of BaO and BaO-PF127-LO was investigated. MTT assay was performed to determine the anticancer potential while the DPPH free radical scavenging assay was carried out to determine the antioxidant potential. The experiment study revealed that the BaO-PF127-LO exhibited enhanced antimicrobial, antioxidant, and anticancer activity and low toxicity when compared to pristine BaO. The experimental results revealed that the BaO-PF127-LO composite holds promising potential for biomedical applications.
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Springer Science and Business Media LLC
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