Green synthesized AgNPs using Clitoria ternatea extract and its confinement on SBA-15/GPTMS-TAEA for controlled drug release of ciprofloxacin

Ag nanoparticles (Ag NPs) were synthesized using Clitoria ternatea plant extract and confined onto mesoporous SBA-15, functionalized with 3-glycidoxypropyl trimethoxysilane followed by tris (2-amino ethyl) amine (SBA-15/GPTMS-TAEA). The sequential grafting of TAEA, GPTMS, and confinement of Ag NPs on the mesoporous SBA-15 was verified by various spectroscopic and microscopic techniques such as FT-IR, SEM, TEM-EDX, XRD, SAXRD, BET, TGA, Si NMR, and C MAS NMR analysis. HR-TEM analysis revealed that the mean diameter of green synthesized Ag NPs is 6–8 nm and the successful confinement of Ag NPs inside the pores of SBA-15/GPTMS-TAEA. The synthesized SBA-15/GPTMS-TAEA-Ag was used are a carrier for binding ciprofloxacin and the controlled drug release of ciprofloxacin was monitored on a UV–Vis spectrophotometer. In Vitro, the loading and release of Ciprofloxacin were found to be 19.8% and 98.14% of the loaded Ciprofloxacin. The kinetic models deducted from the release study demonstrated that SBA-15/GPTMS-TAEA-Ag is a potential carrier for the controlled release of Ciprofloxacin.