Preparation and the biodistribution study of [I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and 5-(4-aminophenyl)-10,15,20-triphenylporphyrin
Journal of Radioanalytical and Nuclear Chemistry, ISSN: 1588-2780, Vol: 302, Issue: 1, Page: 123-130
2014
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Article Description
[I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and [I]-5-(4-aminophenyl)-10,15,20-triphenylporphyrin (I-TPPOH and I-TPPNH) were prepared and their biodistribution properties were evaluated in normal Kunming (KM) mice and SMMC-7721 tumor-bearing BALB/c mice. The optimized labeling yields were 98 and 96 % for I-TPPOH and I-TPPNH, respectively. They were stable in vitro saline and in vivo. Both compounds had a specific affinity to liver and lung, and mainly metabolized through liver. They showed a time-dependent accumulation and retainable characteristics in SMMC-7721 tumor. These results supported their potential value for targeted tumor therapy agents.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84939891489&origin=inward; http://dx.doi.org/10.1007/s10967-014-3269-9; http://link.springer.com/10.1007/s10967-014-3269-9; http://link.springer.com/content/pdf/10.1007/s10967-014-3269-9; http://link.springer.com/content/pdf/10.1007/s10967-014-3269-9.pdf; http://link.springer.com/article/10.1007/s10967-014-3269-9/fulltext.html; https://dx.doi.org/10.1007/s10967-014-3269-9; https://link.springer.com/article/10.1007/s10967-014-3269-9
Springer Science and Business Media LLC
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