A novel radiolabeled indole derivative as solid tumor imaging agent: in silico and preclinical pharmacological study
Journal of Radioanalytical and Nuclear Chemistry, ISSN: 1588-2780, Vol: 314, Issue: 3, Page: 2263-2269
2017
- 14Citations
- 8Captures
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Article Description
Biologically active indole derivative was synthesized and screened for its cytotoxicity against breast cancer cell line (MCF-7) with the IC equals 17.5 µg/mL. Docking study showed its high binding affinity to the COX-2 enzyme. It’s radiolabeling with Tc and showed high radiochemical yield (92.10 ± 0.57%) and in vitro stability in serum up to 10 h. Biodistribution studies of a novel Tc-NSIC complex in tumor-bearing mice showed high T/NT ratio (6.17 ± 0.08 at 30 min. post-injection), suggesting this complex could be used as a solid tumor imaging agent.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85034267165&origin=inward; http://dx.doi.org/10.1007/s10967-017-5551-0; http://link.springer.com/10.1007/s10967-017-5551-0; http://link.springer.com/content/pdf/10.1007/s10967-017-5551-0.pdf; http://link.springer.com/article/10.1007/s10967-017-5551-0/fulltext.html; https://dx.doi.org/10.1007/s10967-017-5551-0; https://link.springer.com/article/10.1007/s10967-017-5551-0
Springer Nature
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