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Studyon biological effect of a kind of hetero-bimetallic Schiff-base on Escherichia coli

Journal of Thermal Analysis and Calorimetry, ISSN: 1388-6150, Vol: 89, Issue: 3, Page: 881-885
2007
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Article Description

The biological activity of a kind of hetero-bimetallic Schiff-base complex was studied using Escherichia coli (E. coli) cell as the target. By microcalorimetry, the difference of anti-bacterial activity between the binuclear Schiff-base and the ligand was determined and analyzed. To analyze the inhibition of the bacterial growth internally, the E. coli cells grown in the presence of hetero-bimetallic Schiff-base complex were observed by scanning electron microscopy. The images in high resolution revealed the damage of outer cell membrane caused the inhibitory effect on E. coli. Inductively coupled plasma-mass spectrometry results proved the absorption of the complex by cells, which confirmed the interaction between the Schiff-base and biological macromolecule. © 2007 Springer Science+Business Media LLC.

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