Study of equilibrium solution and thermodynamic models in correlation with solubility data of rivastigmine tartrate in (HO + isopropanol), (HO + ethanol), and (HO + acetonitrile) binary solvent mixtures
Journal of Thermal Analysis and Calorimetry, ISSN: 1588-2926, Vol: 136, Issue: 2, Page: 815-832
2019
- 5Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures5
- Readers5
Article Description
Millions of people around the world have been suffering from Alzheimer’s disease (AD) everyday. Rivastigmine tartrate is a potential AD drug. A crystallization process can enhance purities of rivastigmine tartrate properly. Predictive models for solubilities of rivastigmine tartrate will improve subsequent industrial crystallization process design. In this work, the solubility of rivastigmine tartrate in (HO + isopropanol), (HO + ethanol), and (HO + acetonitrile) binary solvent systems in the temperature range of 278.15–333.15 K under atmospheric pressure was measured and investigated by employing the analytical stirred-flask method. Binary solvent systems of rivastigmine tartrate overcame drawbacks of mono-solvent crystallization systems, such as high viscosity. Three thermodynamic models, including modified Apelblat equation, the general cosolvency model, and the Jouyban–Acree model, were employed to correlate with the obtained experimental solubility data. Moreover, the calculations of apparent thermodynamic properties of rivastigmine tartrate dissolution process involving the Gibbs free energy, enthalpy, and entropy were accomplished by using the van’t Hoff analysis. Among the three models, the modified Apelblat equation is the most suitable one for predicting the solubility behavior of rivastigmine tartrate in binary solvent systems. Based on the data from modified Apelblat equation, a crystallization process of (HO + ethanol) binary solvent mixture was developed.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85053260921&origin=inward; http://dx.doi.org/10.1007/s10973-018-7684-y; http://link.springer.com/10.1007/s10973-018-7684-y; http://link.springer.com/content/pdf/10.1007/s10973-018-7684-y.pdf; http://link.springer.com/article/10.1007/s10973-018-7684-y/fulltext.html; https://dx.doi.org/10.1007/s10973-018-7684-y; https://link.springer.com/article/10.1007/s10973-018-7684-y
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know