Thermal analysis, structure, spectroscopy and DFT calculations of a pharmaceutical cocrystal of salicylic acid and salicylamide
Journal of Thermal Analysis and Calorimetry, ISSN: 1588-2926, Vol: 138, Issue: 2, Page: 1207-1220
2019
- 8Citations
- 13Captures
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Article Description
The pharmaceutical cocrystal of salicylic acid (CHO or HSal) and salicylamide (CHNO or SAM) was synthesized and characterized by various techniques. The differential scanning calorimetry results confirmed the eutectic fusion showing the characteristic of the endothermic sharp peak of the solidus temperature at 108 °C. X-ray crystal structure of cocrystal is orthorhombic with space group Pna2(1). Cocrystal consists of HSal and a distorted phenolic group of SAM. The packing diagram of cocrystal HSal·SAM clearly confirmed the R82 acid–amide dimer heterosynthons and other inter- and intramolecular interaction bonds to stabilize the structure. In addition, the strength of the hydrogen bonds is studied using the vibrational spectral measurements, confirming the band shifting due to the intermolecular interactions. The identity of compounds by matching the absorbance spectrum was confirmed by ultraviolet spectroscopy technique. Furthermore, the experimental studies were supported by calculation results using density functional B3LYP methods with the standard 6-311++G(d,p) basis set level. The parameters such as bond lengths, bond angles and Mulliken atomic charges values have been calculated and compared, confirmed the interactions and charge transfers. The frontier molecular orbitals (HOMO–LUMO) illustrated the lower band-gap value suggesting the possible pharmaceutical activity of this as obtained HSal·SAM cocrystal.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85074209980&origin=inward; http://dx.doi.org/10.1007/s10973-019-08794-5; http://link.springer.com/10.1007/s10973-019-08794-5; http://link.springer.com/content/pdf/10.1007/s10973-019-08794-5.pdf; http://link.springer.com/article/10.1007/s10973-019-08794-5/fulltext.html; https://dx.doi.org/10.1007/s10973-019-08794-5; https://link.springer.com/article/10.1007/s10973-019-08794-5
Springer Science and Business Media LLC
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