PlumX Metrics
Embed PlumX Metrics

Disease causing mutations of troponin alter regulated actin state distributions

Journal of Muscle Research and Cell Motility, ISSN: 1573-2657, Vol: 33, Issue: 6, Page: 493-499
2012
  • 12
    Citations
  • 0
    Usage
  • 8
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Striated muscle contraction is regulated primarily through the action of tropomyosin and troponin that are bound to actin. Activation requires Ca binding to troponin and/or binding of high affinity myosin complexes to actin. Mutations within components of the regulatory complex may lead to familial cardiomyopathies and myopathies. In several cases examined, either physiological or pathological changes in troponin alter the distribution among states of actin-tropomyosin-troponin that differ in their abilities to stimulate myosin ATPase activity. These observations open possibilities for managing disorders of the troponin complex. Furthermore, analyses of mutant forms of troponin give insights into the regulation of striated muscle contraction. © 2012 Springer Science+Business Media B.V.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know