Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine
Molecular and Cellular Biochemistry, ISSN: 0300-8177, Vol: 310, Issue: 1-2, Page: 209-214
2008
- 36Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef28
- Captures17
- Readers17
- 17
Article Description
Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione, increased activities of glutathione S-transferase, and glutathione peroxidase were observed in liver of NDEA-treated rats when compared with control rats. The activities of superoxide dismutase and catalase were significantly decreased in tumor tissue when compared with control. Administration of S-allylcysteine (SAC) showed the inhibition of tumor incidence, modulated the lipid peroxidation, and increased the reduced glutathione, glutathione-dependent enzymes, superoxide dismutase, and catalase in NDEA-induced carcinogenesis. From our results, we speculate that S-allylcysteine mediates its chemopreventive effects by modulating lipid peroxidation, GST stimulation, and by increasing the antioxidants. Hence SAC prevents cells from loss of oxidative capacity in NDEA-induced hepatocarcinogenesis. © Springer Science+Business Media, LLC. 2008.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=39949085057&origin=inward; http://dx.doi.org/10.1007/s11010-007-9682-4; http://www.ncbi.nlm.nih.gov/pubmed/18185914; http://link.springer.com/10.1007/s11010-007-9682-4; http://www.springerlink.com/index/10.1007/s11010-007-9682-4; http://www.springerlink.com/index/pdf/10.1007/s11010-007-9682-4; https://dx.doi.org/10.1007/s11010-007-9682-4; https://link.springer.com/article/10.1007/s11010-007-9682-4
Springer Science and Business Media LLC
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