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Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents

Molecular Diversity, ISSN: 1573-501X, Vol: 22, Issue: 2, Page: 323-333
2018
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Article Description

Abstract: We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 μ M concentration, cell arrest was observed in the G2/M phase.

Bibliographic Details

Yan, Longjia; Wang, Hui; Chen, Yunpeng; Li, Zhiwei; Pei, Yazhong

Springer Nature

Chemical Engineering; Computer Science; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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