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A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents

Molecular Diversity, ISSN: 1573-501X, Vol: 26, Issue: 5, Page: 2967-2980
2022
  • 50
    Citations
  • 0
    Usage
  • 55
    Captures
  • 0
    Mentions
  • 65
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    50
  • Captures
    55
  • Social Media
    65
    • Shares, Likes & Comments
      65
      • Facebook
        65

Review Description

Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen and or oxygen as heteroatoms in their structures. Several research groups have synthesized diversely substituted 1,2,4-oxadiazoles as anti-infective agents having anti-bacterial, anti-viral, anti-leishmanial, etc. activities. For the first time, the present review article will provide the coverage of synthetic account of 1,2,4-oxadiazoles as anti-infective agents along with their potential for SAR, activity potential, promising target for mode of action. The efforts have been made to provide the chemical intuitions to the reader to design new chemical entity with potential of anti-infective activity. This review will mark the impact as the valuable, comprehensive and pioneered work along with the library of synthetic strategies for the organic and medicinal chemists for further refinement of 1,2,4-oxadiazole as anti-infective agents. Graphical abstract: [Figure not available: see fulltext.]

Bibliographic Details

Tejas M. Dhameliya; Shrddhaba J. Chudasma; Tanvi M. Patel; Bhavarth P. Dave

Springer Science and Business Media LLC

Chemical Engineering; Computer Science; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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