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Comparison of killing activity of micafungin against six Candida species isolated from peritoneal and pleural cavities in RPMI-1640, 10 and 30% serum

Mycopathologia, ISSN: 1573-0832, Vol: 183, Issue: 6, Page: 905-912
2018
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Article Description

Currently echinocandins are recommended in Candida peritonitis and pleuritis. We determined micafungin killing rates (k values) at therapeutic concentrations (0.25-2 mg/L) in RPMI1640 with and without 10 and 30% serum mimicking in vivo conditions against six Candida species isolated from peritoneal and pleural fluid. In RPMI-1640, micafungin was fungicidal against C. glabrata, C. krusei and C. kefyr within 2.27 ± 10.68, 2.69 ± 10.29 and 3.10 ± 4.41 h, respectively, while was fungistatic against C. albicans, C. tropicalis and C. parapsilosis. In 10% serum, ≥ 25, ≥ 0.5, ≥ 0.5 and ≥ 1mg/L micafungin produced positive k values (killing) for all C. albicans, C. glabrata, C. kefyr and C. krusei, respectively. In 30% serum, 2 mg/L micafungin produced killing against all C. albicans, C. glabrata and C. kefyr isolates, but was ineffective against C. krusei, C. parapsilosis and 2 of 3 C. tropicalis. Micafungin exposure should be increased against non-albicans species to eradicate fungi from peritoneal and pleural cavities.

Bibliographic Details

Tóth, Zoltán; Kardos, Tamás; Kovács, Renátó; Kardos, Gábor; Nagy, Fruzsina; Prépost, Eszter; Barta, Zsolt; Takacs, István; Majoros, László

Springer Science and Business Media LLC

Immunology and Microbiology; Agricultural and Biological Sciences; Veterinary

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