Involvement of dopamine D and D receptors in the rat nucleus accumbens in immunostimulation
Neuroscience and Behavioral Physiology, ISSN: 0097-0549, Vol: 37, Issue: 2, Page: 147-151
2007
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Article Description
Analysis of the nature of changes in the immune response in operated Wistar rats showed that electrolytic lesioning of the nucleus accumbens, the site of the greatest density of dopamine D and D receptors, led to suppression of the immune response in animals immunized with sheep erythrocytes. Administration of SKF 38393 (20 mg/kg) and quinpirol (1 mg/kg), selective agonists of dopamine D and D receptors respectively, to sham-operated rats induced significant increases in immune responses. However, no immunostimulation was seen on administration of the selective dopamine D agonist quinpirol to animals with lesions to the nucleus accumbens as compared with controls. At the same time, treatment of animals with nucleus accumbens lesions using the dopamine D receptor agonist SKF 38393 had no effect on the immune response as compared with that in sham-operated animals given the D receptor agonist. These data provide evidence that dopamine D receptors in the nucleus accumbens have a role in the mechanisms of immunostimulation, though D receptors in other brain structures may also make some contribution to this process; D receptors in the nucleus accumbens make no significant contribution to controlling the immune response. © Springer Science+Business Media, Inc. 2007.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845889779&origin=inward; http://dx.doi.org/10.1007/s11055-007-0162-9; http://www.ncbi.nlm.nih.gov/pubmed/17187206; http://link.springer.com/10.1007/s11055-007-0162-9; https://dx.doi.org/10.1007/s11055-007-0162-9; https://link.springer.com/article/10.1007/s11055-007-0162-9; http://www.springerlink.com/index/10.1007/s11055-007-0162-9; http://www.springerlink.com/index/pdf/10.1007/s11055-007-0162-9
Springer Science and Business Media LLC
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