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Involvement of dopamine D and D receptors in the rat nucleus accumbens in immunostimulation

Neuroscience and Behavioral Physiology, ISSN: 0097-0549, Vol: 37, Issue: 2, Page: 147-151
2007
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Analysis of the nature of changes in the immune response in operated Wistar rats showed that electrolytic lesioning of the nucleus accumbens, the site of the greatest density of dopamine D and D receptors, led to suppression of the immune response in animals immunized with sheep erythrocytes. Administration of SKF 38393 (20 mg/kg) and quinpirol (1 mg/kg), selective agonists of dopamine D and D receptors respectively, to sham-operated rats induced significant increases in immune responses. However, no immunostimulation was seen on administration of the selective dopamine D agonist quinpirol to animals with lesions to the nucleus accumbens as compared with controls. At the same time, treatment of animals with nucleus accumbens lesions using the dopamine D receptor agonist SKF 38393 had no effect on the immune response as compared with that in sham-operated animals given the D receptor agonist. These data provide evidence that dopamine D receptors in the nucleus accumbens have a role in the mechanisms of immunostimulation, though D receptors in other brain structures may also make some contribution to this process; D receptors in the nucleus accumbens make no significant contribution to controlling the immune response. © Springer Science+Business Media, Inc. 2007.

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