Melatonin in Chronic Pain Syndromes
Neuroscience and Behavioral Physiology, ISSN: 1573-899X, Vol: 47, Issue: 7, Page: 806-812
2017
- 6Citations
- 39Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Melatonin is a neurohormone synthesized in the pineal gland and extrapineal structures and has a number of functions, including chronobiotic, antioxidant, oncostatic, immunomodulatory, normothymic, and anxiolytic actions, the abilities to affect the cardiovascular system and the gastrointestinal tract and take part in reproductive functions, and a role in regulating substance metabolism and body weight. In addition, recent studies have demonstrated the efficacy of melatonin in relation to pain syndromes. We present here a review of studies of the use of melatonin in fibromyalgia, headaches, irritable bowel syndrome, chronic back pain, and rheumatoid arthritis. The possible mechanisms mediating the analgesic properties of melatonin are discussed. On the one hand, normalization of circadian rhythms, which are inevitably deranged by chronic pain syndromes, improves sleep and activates the intrinsic adaptive potential of melatonin; on the other, data have been obtained showing that melatonin has independent analgesic influences mediated via melatonin receptors and various neurotransmitter systems.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029010906&origin=inward; http://dx.doi.org/10.1007/s11055-017-0472-5; http://link.springer.com/10.1007/s11055-017-0472-5; http://link.springer.com/content/pdf/10.1007/s11055-017-0472-5.pdf; http://link.springer.com/article/10.1007/s11055-017-0472-5/fulltext.html; https://dx.doi.org/10.1007/s11055-017-0472-5; https://link.springer.com/article/10.1007/s11055-017-0472-5
Springer Science and Business Media LLC
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