Immunological and Neuroanatomical Markers for the Dynamics of Predementia Cognitive Disorders during Neurorehabilitation
Neuroscience and Behavioral Physiology, ISSN: 1573-899X, Vol: 54, Issue: 9, Page: 1333-1342
2024
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Objectives. To study the relationship between measures of immunity and systemic inflammation and structural magnetic resonance imaging (MRI) indicators in patients with pre-dementia cognitive disorders (pre CI) during neurocognitive rehabilitation with the aim of identifying candidate markers for the efficacy of this rehabilitation. Materials and methods. The study group consisted of 49 patients with preMCI with memory impairments; patients were aged 60 years and older and underwent five-week neurorehabilitation courses. The control group consisted of 19 volunteers of similar age without cognitive disorders or immune-inflammatory disorders. Measures of cellular and humoral immunity and inflammatory markers were determined and structural MRI was performed. Results. preMCI was found to be associated with an elevated content of activated natural killers (NK cells) (0.63 ± 0.12% versus 0.22 ± 0.07% in the control group, p = 2.2 10). Immunoglobulin G (IgG) levels of <12.5 g/liter in patients with preMCI and scores of <22 on the Montreal Cognitive Assessment (MoCA) were associated with decreases in the volume of the right nucleus accumbens (376 ± 35 mm with IgG <12.5 g/liter (p = 0.0013), 429 ± 40 mm at IgG >12.5 g/liter, and 480 ± 44 mm in the control group), as well as the thickness and volume of some other cortical areas. A logistic regression model (R = 0.57; p < 1 10; standard error of estimate 2.93) was built, including immunoglobulin G, NK cells, CD8 NK cell levels, and the volume of the right amygdala, which predicted MoCA scores six months after rehabilitation courses. Conclusions. These studies provide the first demonstration that immune parameters in combination with socio-demographic data and brain morphometric indexes are highly significant as potential prognostic markers reflecting the response to neurorehabilitation.
Bibliographic Details
Springer Science and Business Media LLC
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