Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats
Neurochemical Research, ISSN: 0364-3190, Vol: 38, Issue: 3, Page: 530-537
2013
- 19Citations
- 18Captures
- 3Mentions
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef10
- Captures18
- Readers18
- 18
- Mentions3
- References3
- Wikipedia3
Article Description
Anesthetics such as propofol can provide neuroprotective effects against cerebral ischemia. However, the underlying mechanism of this beneficial effect is not clear. Therefore, we subjected male Sprague-Dawley rats to 2 h of middle cerebral artery occlusion and investigated how post-ischemic administration of propofol affected neurologic outcome and the expression of basic fibroblast growth factor (bFGF). After 2 h of ischemia, just before reperfusion, the animals were randomly assigned to receive either propofol (20 mg kg h) or vehicle (10 % intralipid, 2 ml kg h ) intravenously for 4 h. Neurologic scores, infarct volume, and brain water content were measured at different time points after reperfusion. mRNA level of bFGF was measured by real-time PCR, and the protein expression level of bFGF was analyzed by immunohistochemistry and Western blot. At 6, 24, 72 h, and 7 days of reperfusion, infarct volume was significantly reduced in the propofol-treated group compared to that in the vehicle-treated group (all P < 0.05). Propofol post-treatment also attenuated brain water content at 24 and 72 h and reduced neurologic deficit score at 72 h and 7 days of reperfusion (all P < 0.05). Additionally, in the peri-infarct area, bFGF mRNA and protein expression were elevated at 6, 24, and 72 h of reperfusion compared to that in the vehicle-treated group (all P < 0.05). These results show that post-ischemic administration of propofol provides neural protection from cerebral ischemia-reperfusion injury. This protection may be related to an early increase in the expression of bFGF. © 2012 Springer Science+Business Media New York.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876407306&origin=inward; http://dx.doi.org/10.1007/s11064-012-0945-4; http://www.ncbi.nlm.nih.gov/pubmed/23247820; http://link.springer.com/10.1007/s11064-012-0945-4; https://dx.doi.org/10.1007/s11064-012-0945-4; https://link.springer.com/article/10.1007/s11064-012-0945-4; http://link.springer.com/article/10.1007%2Fs11064-012-0945-4; https://link.springer.com/content/pdf/10.1007%2Fs11064-012-0945-4.pdf; http://link.springer.com/content/pdf/10.1007/s11064-012-0945-4; https://link.springer.com/content/pdf/10.1007/s11064-012-0945-4.pdf
Springer Science and Business Media LLC
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