Synthesis of New Thiadiazole-2-Oxides as Potential Antischistosomal Agents
Pharmaceutical Chemistry Journal, ISSN: 1573-9031, Vol: 55, Issue: 10, Page: 1028-1032
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures4
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Article Description
Schistosomiasis is a chronic infectious disease that affects millions of people worldwide, of which chemotherapy with praziquantel as the only available drug is the main method of control in view of the absence of effective vaccines. In this study, a series of new thiadiazole 2-oxides were synthesized as potential antischistosomal agents and evaluated in vitro for antischistosomal activity on Schistosoma japonicum adult worms. The results revealed that compound 10a (3-cyano-4-phenyl-1,2,5-thiadiazole 2-oxide) exhibited more potent worm killing activity compared to praziquantel and oxadiazole 2-oxide, which provided possible opportunity for the development of new antischistosomal drugs.
Bibliographic Details
Springer Science and Business Media LLC
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