Impact of excipient interactions on solid dosage form stability
Pharmaceutical Research, ISSN: 0724-8741, Vol: 29, Issue: 10, Page: 2660-2683
2012
- 105Citations
- 184Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations105
- Citation Indexes103
- 103
- CrossRef53
- Patent Family Citations2
- 2
- Captures184
- Readers184
- 184
Review Description
Drug-excipient interactions in solid dosage forms can affect drug product stability in physical aspects such as organoleptic changes and dissolution slowdown, or chemically by causing drug degradation. Recent research has allowed the distinction in chemical instability resulting from direct drug-excipient interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms highlights common mechanistic themes applicable to multiple degradation pathways. These common themes include the role of water and microenvironmental pH. In addition, special aspects of solid-state reactions with excipients and/or excipient impurities add to the complexity in understanding and modeling reaction pathways. This paper discusses mechanistic basis of known drug-excipient interactions with case studies and provides an overview of common underlying themes. Recent developments in the understanding of degradation pathways further impact methodologies used in the pharmaceutical industry for prospective stability assessment. This paper discusses these emerging aspects in terms of limitations of drug-excipient compatibility studies, emerging paradigms in accelerated stability testing, and application of mathematical modeling for prediction of drug product stability. © Springer Science+Business Media, LLC 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866740301&origin=inward; http://dx.doi.org/10.1007/s11095-012-0782-9; http://www.ncbi.nlm.nih.gov/pubmed/22707362; http://link.springer.com/10.1007/s11095-012-0782-9; http://www.springerlink.com/index/10.1007/s11095-012-0782-9; http://www.springerlink.com/index/pdf/10.1007/s11095-012-0782-9; https://dx.doi.org/10.1007/s11095-012-0782-9; https://link.springer.com/article/10.1007/s11095-012-0782-9
Springer Science and Business Media LLC
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