Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?
International Journal of Clinical Pharmacy, ISSN: 2210-7703, Vol: 37, Issue: 5, Page: 682-686
2015
- 2Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations2
- Citation Indexes2
- CrossRef2
- Captures26
- Readers26
- 26
Article Description
Case (description): We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes. Conclusion: Our results may suggest a role of the UGT2B7-372A>G polymorphism in this reaction.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943170676&origin=inward; http://dx.doi.org/10.1007/s11096-015-0158-4; http://www.ncbi.nlm.nih.gov/pubmed/26173940; http://link.springer.com/10.1007/s11096-015-0158-4; https://dx.doi.org/10.1007/s11096-015-0158-4; https://link.springer.com/article/10.1007/s11096-015-0158-4
Springer Science and Business Media LLC
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