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Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?

International Journal of Clinical Pharmacy, ISSN: 2210-7703, Vol: 37, Issue: 5, Page: 682-686
2015
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Article Description

Case (description): We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes. Conclusion: Our results may suggest a role of the UGT2B7-372A>G polymorphism in this reaction.

Bibliographic Details

Provenzani, Alessio; Labbozzetta, Manuela; Notarbartolo, Monica; Poma, Paola; Polidori, Piera; Vizzini, Giovanni; D'Alessandro, Natale

Springer Science and Business Media LLC

Health Professions; Pharmacology, Toxicology and Pharmaceutics; Medicine

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