New derivatives of dehydroabiethylamine and adamantane: synthesis and activity as inhibitors of the repair enzyme TDP1
Russian Chemical Bulletin, ISSN: 1573-9171, Vol: 73, Issue: 6, Page: 1829-1835
2024
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Article Description
A number of new conjugates of dehydroabiethylamine and adamantane was obtained using a three-step synthetic scheme in order to study the effect of linker type and length on biological activity. The inhibitory activity of the synthesized compounds toward the DNA repair enzyme Tyrosyl-DNA phosphodiesterase 1 was studied. The compounds are potent inhibitors, exhibiting activity in micromolar concentrations.
Bibliographic Details
Springer Science and Business Media LLC
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