G protein-coupled adenosine (P1) and P2Y receptors: Ligand design and receptor interactions
Purinergic Signalling, ISSN: 1573-9538, Vol: 8, Issue: 3, Page: 419-436
2012
- 77Citations
- 159Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations77
- Citation Indexes76
- 76
- CrossRef44
- Patent Family Citations1
- Patent Families1
- Captures159
- Readers159
- 159
Article Description
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands. X-ray crystallographic structures of both agonist- and antagonist-bound forms of the AAR have provided unprecedented three-dimensional detail concerning molecular recognition in the binding site and the conformational changes in receptor activation. It is apparent that this ubiquitous cell signaling system has implications for understanding and treating many diseases. ATP and other nucleotides are readily released from intracellular sources under conditions of injury and organ stress, such as hypoxia, ischemia, or mechanical stress, and through channels and vesicular release. Adenosine may be generated extracellularly or by cellular release. Therefore, depending on pathophysiological factors, in a given tissue, there is often a tonic activation of one or more of the ARs or P2YRs that can be modulated by exogenous agents for a beneficial effect. Thus, this field has provided fertile ground for pharmaceutical development, leading to clinical trials of selective receptor ligands as imaging agents or for conditions including cardiac arrhythmias, ischemia/reperfusion injury, diabetes, pain, thrombosis, Parkinson's disease, rheumatoid arthritis, psoriasis, dry eye disease, pulmonary diseases such as cystic fibrosis, glaucoma, cancer, chronic hepatitis C, and other diseases. © 2012 Springer Science+Business Media B.V. (outside the USA).
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861528253&origin=inward; http://dx.doi.org/10.1007/s11302-012-9294-7; http://www.ncbi.nlm.nih.gov/pubmed/22371149; http://link.springer.com/10.1007/s11302-012-9294-7; http://www.springerlink.com/index/10.1007/s11302-012-9294-7; http://www.springerlink.com/index/pdf/10.1007/s11302-012-9294-7; https://dx.doi.org/10.1007/s11302-012-9294-7; https://link.springer.com/article/10.1007/s11302-012-9294-7
Springer Science and Business Media LLC
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