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Acoschimperoside P, 2′-acetate: A Hedgehog signaling inhibitory constituent from Vallaris glabra

Journal of Natural Medicines, ISSN: 1340-3443, Vol: 65, Issue: 3-4, Page: 629-632
2011
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Article Description

Complete H and C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1. © 2011 The Japanese Society of Pharmacognosy and Springer.

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