New advanced glycation end-products inhibitors from Dichrostachys cinerea Wight & Arn.
Journal of Natural Medicines, ISSN: 1340-3443, Vol: 66, Issue: 1, Page: 213-216
2012
- 13Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef6
- Captures13
- Readers13
- 13
Review Description
Free radical scavenging and advanced glycation end-product (AGE) inhibitory potential were evaluated in the crude methanol extract of Dichrostachys cinerea. Bioassay-guided isolation led to the identification of four flavan-3-ols, namely (-)-mesquitol (1), oritin (2), (-)-festidinol (3) and (-)-epicatechin (4). Analysis of structure-activity relationships revealed that the presence of 7,8-dihydroxyl groups in the A-ring of flavan-3-ols in conjunction with 3′,4′-dihydroxyls in the B-ring (1) is an important criterion for displaying potent AGE inhibitory activity along with free radical scavenging properties. (-)-Mesquitol (1), oritin (2), and (-)-festidinol (3) were found to be new natural AGE inhibitors. (-)-Mesquitol (1) displayed the most potent AGE inhibitory activity. Results suggest that (-)-mesquitol (1) may serve as an important natural organic lead compound for future development of antiglycating agents along with potent antioxidant activity. © The Japanese Society of Pharmacognosy and Springer 2011.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84856210018&origin=inward; http://dx.doi.org/10.1007/s11418-011-0557-3; http://www.ncbi.nlm.nih.gov/pubmed/21706215; http://link.springer.com/10.1007/s11418-011-0557-3; https://dx.doi.org/10.1007/s11418-011-0557-3; https://link.springer.com/article/10.1007/s11418-011-0557-3; http://www.springerlink.com/index/10.1007/s11418-011-0557-3; http://www.springerlink.com/index/pdf/10.1007/s11418-011-0557-3
Springer Science and Business Media LLC
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