Macrocarquinoids A–C, new meroterpenoids from Sargassum macrocarpum
Journal of Natural Medicines, ISSN: 1861-0293, Vol: 75, Issue: 1, Page: 194-200
2021
- 8Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- Captures9
- Readers9
Article Description
Abstract: The production and accumulation of advanced glycation end products (AGEs) have been implicated in diabetes and diabetic complication. This study was conducted as a search for an AGE inhibitor from brown alga, Sargassum macrocarpum. Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC: 1.0 mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control). Graphic abstract: [Figure not available: see fulltext.].
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091685288&origin=inward; http://dx.doi.org/10.1007/s11418-020-01449-y; http://www.ncbi.nlm.nih.gov/pubmed/32974814; https://link.springer.com/10.1007/s11418-020-01449-y; https://dx.doi.org/10.1007/s11418-020-01449-y; https://link.springer.com/article/10.1007/s11418-020-01449-y
Springer Science and Business Media LLC
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